Dr Conners answers the question, “Are There Specific Gene Defects Involved in Breast Cancer?” on the Breast Cancer Conqueror podcast with Dr. V 💚

Watch, listen to, or read the whole interview on the the Breast Cancer Conqueror Podcast with Dr. Véronique Desaulniers!


Are There Specific Gene Defects Involved in Breast Cancer?


Dr V:
Now, what are your, well let’s talk about breast cancer specific. Are there specific genes that you have seen that are involved typically in the development of breast cancer, other than, you know, the BRCA gene, which I’d like to ask you about also. Because we say BRCA and everybody freaks out, but they don’t realize it’s a tumor suppressor gene. It’s a good gene, you know, and why does it, why does it mutate? It doesn’t, you know, it’s not always genetic. So, lets address that. Breast cancer specifically.

Dr V:
So breast cancer specifically, there are certain genes that you want to look for for breast cancer. Certainly the BRCA genes are just one. Those are tumor suppressor genes, not just in breast cancer, but any hormonally-driven cancers. And what people struggle with, with the BRCA genes is that typically if they go through their oncologist, they’re only gonna check two, three, four, five of the main BRCA genes, where there’s dozens and dozens of BRCA genes. And so most people will have multiple defects on their BRCA genes and that can be very normal. So you have to be careful to calm the person when you go over their genes because the person could be stuck in thinking that if I have a defect, I’m going to get a disease. That’s not true. But you definitely look at the BRCA genes with any type of hormonally-driven cancer.

Dr C:
And then you have to be looking at detoxification pathway genes, and maybe even more important than the tumor suppressor genes. It’s that detoxification genes. And not just breast cancer, but most cancers because remember something had to get inside the cell to cause that rapid replication in the first place. Could it be a virus? Well, yes, it could be that it’s really not going to be effected by the tumor or the detoxification pathway genes, but more often than not, it’s some sort of toxic chemical that we’re exposed to hence the rise in cancers across the world in the last 50 years because the rise of chemical use, and how that correlates. So it’s the slowing of our detox pathways that causes defects. That is probably our biggest genetic cause of cancer, though it’s indirect.