Palladium Lipoic Acid Complex (PdLA) is the most active ingredient in a dietary supplement called Poly-MVA. In the palladium lipoic acid complex, the element palladium is covalently bound to the anti-oxidant alpha-lipoic acid, a potent ‘cancer killer’. In addition to PdLA, the proprietary blend of Poly-MVA is formulated with minerals, vitamins and amino acids such as molybdenum, rhodium, ruthenium, thiamine, riboflavin, cyanocobalamin, acetyl cysteine, and formyl methionine (Garnett 1995, 1997, 1998). Dr. Merrill Garnett invented Poly-MVA. His inquiry and screening of thousands of organo-metallic compounds led to the discovery of the non-toxic supplement and found it to have potent chemotherapeutic properties.
Poly-MVA, is not merely a cocktail of different nutrients, it is HOW they are put together that makes them work differently. Alpha-lipoic acid (ALA) is a great nutrient by itself working it help liver detox pathways and dozens of other metabolic functions but there is really no free ALA or free palladium in Poly-MVA. They are bound together that makes them function differently and THIS is what makes it a special product. This compound was synthesized by Dr. Garnett to create a ‘metallic bioorganic molecule’ that demonstrates enhanced fat and water-solubility. Furthermore, it is prepared in a unique fashion so it does not produce toxic products upon consumption. This is unlike many other chemotherapeutics, which breakdown, accumulate in tissue and eventually become toxic.
Its unique properties appear to be the key to its physiological effectiveness. When glucose enters a cell, it is broken down under anaerobic conditions (absence of oxygen in glycolysis) into pyruvate. Pyruvate subsequently enters the mitochondria, and is quickly oxidized, in the presence of alpha-lipoic acid (ALA), to acetyl-CoA so that it can enter the Citric Acid Cycle and produce even more energy. In aerobic respiration, acetyl-CoA is then channeled into the Krebs/Citric Acid Cycle to create the reduced forms of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2). NADH and FADH2 donate their electrons to the electron transport chain to make the high energy molecule ATP. This is how your body makes energy.
Recent studies in India (Sudheesh et al., 2009) have demonstrated Palladium Lipoic Acid Complex’s ability to facilitate aerobic metabolism, which is responsible for ATP production in healthy cells. The energy needs of the body are supplied by splitting ATP into adenosine diphosphate (ADP) and a free phosphate (Griffin et al. 2006). Studies have demonstrated that Poly-MVA provides electrons to DNA, via the mitochondria.
Let’s simplify: Poly-MVA helps energy production by providing electrons to speed production. Whenever anything increases electrons to your body, it increases pH as well. That’s all good!
Electrons are lost in normal cells as a result of oxidative damage from radiation and chemotherapy (Garnett and Garnett 1996) – that’s BAD and exactly how poisons work. Poly-MVA electron transfer provides an additional energy source to normal cells that increases pH and overall health. However, cancer cells are metabolically challenged, and function in a hypoxic (without oxygen) environment. Since there is less oxygen and more free electrons in the cancer cell, generation of free radicals occurs at the tumor mitochondrial membrane (Antonawich et al. 2004). This activates apoptosis by facilitating the release of cytochrome C from the inner mitochondrial membrane, allowing the formation of an apoptotic complex in the cytoplasm. This complex, results in the subsequent activation of enzymes that destroy the malignant cells. At significantly higher concentrations of Poly-MVA necrosis becomes apparent in the malignant cell. Given that normal cells are richly oxygenated, Poly-MVA is nontoxic to them and they actually benefit from the energy boost (Antonawich et. al 2006).
So, Poly-MVA appears to be a ‘selective’ metabolic modulator as it increases the apoptotic function of cancer cells (helps them undergo normal cell death) and helps normal cells thrive. But, like every ‘cancer killer’ discussed, it just doesn’t work on everyone. Sometimes (most of the time) a combination of diet, Th1 stimulators and specific ‘killers’ are necessary.