The ONCOblot® blood test was conceived and developed by the husband and wife team of Dr. D. James Morré and Dr. Dorothy M. Morré who are professors emeritus and emerita of Indiana’s Purdue University. Since 1978, Purdue University has been a National Cancer Institute-designated cancer research center. The ONCOblot® test looks for tiny amount of proteins called ENOX2 in the blood. These proteins are produced by cells only when they become cancerous, and are not produced by healthy cells. The ENOX2 proteins are shed into the circulation and can be detected through an advanced patented process. These proteins serve as highly sensitive markers to confirm the presence of cancer. ENOX2 stands for Ecto-Nicotinamide adenine dinucleotide OXidase disulfide-thiol exchanger-2.

What does the ONCOblot® test do?

The ONCOblot® blood test can detect a tiny amount of cancer anywhere in the body, whether it has spread or not. It is estimated this test can find as few as 2 million cancer cells, which roughly corresponds to a 1 to 2mm tumour – about the size of a pin head! Compare this to a mammogram which requires a tumour to contain about 100 – 1000 times more cells (7.5mm in size) before it will be reliably detected! Even if there is no tumour, but there are more than about 2 million cancer cells floating in the blood or lymphatic system, ONCOblot® will detect the cancer with great accuracy.

“Stage 0” cancers are also detected with high accuracy (like DCIS which is a localized cancer of the breast). What is even more impressive is that ONCOblot® also has a very low false-positive rate of less than 1% (the chance of telling you there is cancer in the body when there actually isn’t). This is extremely important because the test would not be useful if it frequently reported the presence of cancer when there was none.

In addition, ONCOblot® can identify the organ that the cancer came from (“tissue of origin”) without a scan or biopsy, with over 96% accuracy. If there are more cancer cells present, the accuracy of identifying the correct organ increases.