Why CitraNOX?

Since NO ONE is stressed out in today’s cancel-culture, you can all skip reading about the benefits of CitraNOX (wink, wink). Stress is pretty much expected in our current culture, especially true in the aging process. This stress easily contributes to disruptions in arterial function, impacting normal cardiac function, proliferation of vascular smooth muscle, a decrease in circulating nitric oxide (NO) levels and eventual vasocontraction of key coronary arteries. CitraNOX is a blend of key ingredients helpful for maintaining normal inflammatory balance, balancing NO levels, maintaining smooth muscle integrity, and optimizing vasodilation of key coronary arteries.

CitraNOX is formulated specifically to help maintain healthy blood pressure levels by enhancing endothelial cell and arterial function. This supplement contains a combination of high-dose L-citrulline, quercetin and grape seed extract, allowing for normal inflammatory balance, arterial elasticity, optimal nitric oxide levels and blood flow. This powerful formula provides support for those seeking to optimize their cardiovascular health.


Orthomolecular states that” L-citrulline is one of the three dietary amino acids in the urea cycle responsible for converting ammonia into urea as well as for the production of NO, an important cellular signaling molecule.” L-citrulline is the natural precursor of L-arginine, which is the substrate used by endothelial nitric oxide synthase to produce NO. NO is a signaling molecule shown to have a very powerful effect on vasodilation and blood flow. Optimizing circulating NO levels has historically been a target of aerobic and anaerobic athletes. Supplementation with L-citrulline and L-arginine have had profound results on exercise performance and power output.

Besides optimizing exercise performance, NO has a variety of unique abilities to benefit bodily function. NO improves arterial elasticity, decreases platelet adhesion, scavenges free radicals and prevents oxidation of LDL cholesterol. Studies have dramatically shown the benefit of NO supplementation through L-citrulline.

Quercetin Dihydrate 

Quercetin is a major player in reducing histamine levels and is found in all of our histamine-lowering supplements. Histamine is an immune stimulant which can be greatly unregulated in cardiovascular disease. Lowering vascular inflammation is the key. Quercetin is a flavonoid found in a variety of botanicals, vegetables and fruits and works as a potent antioxidant that inhibits inducible ICAM-1 expression, an important pathway maintaining normal inflammatory balance. Studies have shown that quercetin supports normal inflammatory balance by directly inhibiting activity of NFkB, which is similar to turmeric. In addition, quercetin is known for its ability to improve endothelial cell dysfunction by sustaining inflammatory balance in specific pathways.

MegaNatural BP Grape Seed Extract

Orthomolecular states that, “MegaNatural BP is a premium grape seed extract made in California from a special seed blend extracted with water from a variety of white wine grape seeds.” Grapes and grape products contain phenolic compounds that have specific health-promoting properties, especially in cardiovascular wellness. Grape seed extract has a high concentration of phenolic compounds, which have been shown to support healthy arterial dilation and blood flow. Studies show that the effects of MegaNatural BP grape seed extract are significant in that it is able to maintain healthy blood pressure levels.


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