Coffee Consumption – Not an Alternative Cancer treatment
Coffee is a Th2 Stimulant and Not for Cancer Patients
Research is proving that it is the Chlorogenic Acid, a component in high concentration in coffee which clearly down-regulates Th1 cytokines and Vitamin D Receptor Sites (VDR) necessary for immune function. Caffeine, although it has some effect on the Type 1 Nuclear Receptors, is not the major player that makes coffee a ‘bad-guy’ for those needing a killer-cell boost.
Chlorogenic acid (yellow backbone in picture below) docks into the VDR, with the gray structure of the docked 1,25-Hydroxy D for comparison shown below.
Chlorogenic Acid forms hydrogen bonds with the same residues as 1,25-D; ARG274, SER237, SER278 and (weaker) TYR143. However, it does not have a ‘tail’ to stabilize the lower part of the VDR receptor, so at best it is a partial agonist, and is more probably a total antagonist of Type 1 Nuclear Receptor activity.
The affinity of Chlorogenic Acid for the VDR is consequently very high according to a paper published in American Journal of Clinical Nutrition, Vol. 78, No. 4, 728-733. Just one cup of coffee contains several orders of magnitude more Chlorogenic acid than would be needed to notice a profound effect on the VDR (and an effect the other Type 1 Nuclear Receptors, such as the Thyroid Receptors).
There is a difference between coffee in enemas vs. oral consumption! Our Modified Gerson approach explains this as well.
Un fermented Soy
(Genistein) has a similar Th2 stimulation, Th1 down-regulation
Genistein, which is an isoflavone, as well as Chlorogenic acid, act as antioxidants that modulate the immune system by stimulating a Th2 response. The quantity of Chlorogenic acid in most plants is miniscule. However, a few plants accumulate Chlorogenic acids in quantities sufficient to have a physiological effect. The primary dietary source of Chlorogenic acid is coffee; green coffee beans typically contain 6-7% of this component (range: 4-10%); roasted coffee beans contain somewhat less, as the roasting transforms Chlorogenic acids into other molecules, which may still retain the same functions. Coffee that is not fresh (two weeks past roasting) is said to contain fewer antioxidants (Chlorogenic acid). Apples, pears and eggplant contain small amounts of Chlorogenic acid. It is somewhat neutralized by an enzyme in the skin of the fruit. Eating these foods in moderation should be fine for autoimmune patients that are Th2 dominant as long as they eat the whole fruit. Dr. Vinson, researcher at the University of Pennsylvania, who has studied decaffeinated coffee said, “both caffeinated and decaffeinated coffee provides similar levels of antioxidants (Chlorogenic acid).”
Cocoa contains Chlorogenic acid but the amount is very small.
Green tea contains some genistein but the amount seems to be very low. If you enjoy green tea, we suggest that you allow the tea bag to steep for 30 seconds or less. Otherwise, green tea becomes a greater Th2 stimulant – preferred if the patient is Th1 dominant.
Patients who are Th1 dominant:
- Moderate amounts of coffee are okay; drink green tea for the other benefits as well
- Must check 25-OH and 1,25-OH Vit D levels
Patients who are Th2 dominant AND Cancer patients:
- Absolutely limit coffee to zero
- Limit apples, pears and eggplant. Eat whole fruit only, no juice or cooked.
- No Unfermented soy – Fermented soy is completely different and can be extremely beneficial in hormonal based cancers (see my book, “A Cancer Primer”, at www.drkevinconners.com)