Why CORE Support?

CORE Support is a formula used to enhance liver detoxification by providing macronutrients, phytonutrients and cofactors that support detoxification of xenobiotics and xenoestrogens. The body is exposed to a wide variety of toxins on a daily basis and the liver is the main detoxification center to safely process and remove unwanted toxins. Detoxification is so important for the body to get rid of these toxins and remove xenobiotics (foreign chemical substances), as well as unhealthy hormone metabolites. These detoxification systems are very complex and require a variety of nutrients for optimal function.

There are two main pathways of detoxification in the liver known as Phase I and Phase II. Phase I is composed mainly of cytochrome P450 enzymes, where non-reactive compounds undergo specific reaction which use oxygen to form a reactive site. More common pharmaceuticals prepare the metabolite for the next step of detoxification, but if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell.

CORE Support ingredients were primarily chosen for their ability to support one of the six pathways of Phase II detoxification. N-acetyl cysteine, along with glycine and taurine, is a well-known amino acid that plays a role in enhancing liver detoxification. Antioxidants such as lipoic acid, green tea, ellagic acid and the vegetable antioxidant blend provide a synergistic approach to liver support and promote enhanced detoxification.

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N-Acetyl Cysteine

N-acetyl cysteine (NAC) is a sulfydryl-containing amino acid that is commonly used to support liver health and protect cellular health. Studies that shown that patients who received NAC have shown a significant increase in circulating levels of glutathione, a primary antioxidant that protects cellular health. Increasing glutathione increases the production of specialized antioxidant enzymes, such as glutathione peroxidase, glutathione reductase and detoxification enzymes such as glutathione S-transferase. With the necessary activity of these enzymes, NAC can protect the body from oxidative damage, increases Phase II detoxification, and enhances the normal breakdown of toxins and other metabolic toxins throughout the body.

Glycine

One of the six Phase II detoxification pathways includes the amino acid conjugation, which is the attachment of amino acids to a toxin. Glycine is necessary for this process. Glycine also aids in the glutathione conjugation and preserves intracellular glutathione concentration, protecting the cells from oxidative damage. Studies have shown that patients who have received glycine treatment have reduced intracellular concentration of reactive oxygen species (ROS) when exposed to oxidative challenges.

Taurine & Lipoic Acid

The sulfation pathway is another important Phase II detoxification pathway. During this specific pathway, a sulfur-containing molecule is attached to the toxin in order to produce a compound that can then be taken out of the body. Research suggests that taurine effectively conjugates bile acids and increases glutathione production. Lipoic acid is a potent antioxidant that has veen shown to increase glutathione, vitamin E and vitamin C levels in the body. Lipoic acid has been shown to support Phase II detoxification by ultimately increasing the acitivity of enzymes including NAD(P)H, quinine oxidoreductase, and glutathione-S-transferase.

Green Tea Extract & Rosemary

Green tea is a highly popular beverage, being the most widely consumed throughout the world. Green tea contains the main polyphenol epigallocatechin-3-gallate (EGCG). Green tea polyphenols have been shown to increase antioxidant protection and enhance liver detoxification. Studies have shown that green tea extract increases Phase II enzymes such as glutathione transferase, NAD(P)H, quinine reductase, epoxide hydrolase, and UDP-glucuronosyltransferase. EGCG allows for cellular defense capacity against chemical toxins, ultraviolet radiation, and oxidative stress. Rosemary includes polyphenols that are potent antioxidants, including carnosol, which contains glutathione-s-transferase, along with many other important Phase II enzymes. Research demonstrates that rosemary essential oil and carnosol have been shown to increase intracellular glutathione levels.

Vegetable Antioxidant Blend 

CORE Support contains a blend of high-concentration superfood vegetables with significant antioxidant abilities. This blend is high in oxygen radical absorbance capacity (ORAC), a method of measuring antioxidant activity, and includes health promoting compounds such as sulforaphane and glucosinolates. This blend includes cruciferous vegetables including broccoli, kale, and brussels sprouts, which increase the enzyme activity of both Phase I and Phase II detoxification pathways. Sulforaphane induces Phase II detoxification enzymes and supports the body’s response to oxidative stress, which ultimately promotes balanced inflammation. Glucosinolates serve as precursors for biologically active metabolites, which induce Phase II enzymes through the activation of Nrf2, the cellular switch responsible for antioxidant production.

Schisandra Berry Extract

Schisandra is an adaptogenic botanical used medicinally to help fight off the physical and mental effects of stress. Schisandra is primarily used to support liver health and neutralize the effects of toxin exposure while increasing the levels of reduced glutathione in the liver as well as glutathione reductase and glutathione-S-transferase activity. Schisandra has also been shown to support Phase I metabolism and protect the liver from free radical damage induced by toxic chemical exposure following ingestion of carbon tetrachloride.

Psyllium Husks

Psyllium husk is from the plant Plantago ovata and contains a large amount of soluble fiber per volume. Psyllium is primarily used to improve gastrointestinal transit time and promotes cardiovascular health by maintaining normal cholesterol levels through the elimination of cholesterol-rich bile. Research demonstrates that psyllium husk powder up-regulates genes involved in bile acid synthesis and binds to bile acids in the intestines to remove them from the body.