Methylation Pathways are Essential
Liver detox pathways are essential to detox poisons as well as cancer cells killed by any method. The methylation pathway is one detox system that is dependent on dietary folate that needs to be either converted to MTHF (methylenetetrahydrofolate) or better, taken orally as MTHF.
There has been a lot of press on the link between MTHFR (methylenetetrahydrofolate reductase) gene mutations and chronic disease. This has resulted in a great deal of concern with the particular form of folate that doctors are giving to their patients.
Learn more about MTHFR mutations here
According to a recent study in the American Journal of Clinical Nutrition, the human gut appears to have a very efficient capacity to convert reduced dietary folates to 5-MTHF, but only a limited ability to reduce folic acid (synthetic folate). The risk occurs when there is unmetabolized folic acid present. Unlike natural folates (5-MTHF and 5-formyltetrahydrofolate), folic acid is not a normal metabolite and must be reduced in order to enter the folate cycle. It has been found that chronic liver exposure to folic acid in humans may actually induce saturation. This could very well be the reason why systemic circulation of unmetabolized folic acid has been reported. In addition, there is a growing body of evidence of folic acid supplementation playing a role in promoting the growth and development of certain cancers.
Source: Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr 2014 ajcn.080507; June 18, 2014.
Methylation Pathways are Essential
Liver detox pathways are essential to detox poisons as well as cancer cells killed by any method. The methylation pathway is one detox system that is dependant on dietary folate that needs to be either converted to MTHF (methylenetetrahydrofolate) or better, taken orally as MTHF.
There has been a lot of press on the link between MTHFR (methylenetetrahydrofolate reductase) gene mutations and chronic disease. This has resulted in a great deal of concern with the particular form of folate that doctors are giving to their patients.
Learn more about MTHFR mutations here
According to a recent study in the American Journal of Clinical Nutrition, the human gut appears to have a very efficient capacity to convert reduced dietary folates to 5-MTHF, but only a limited ability to reduce folic acid (synthetic folate). The risk occurs when there is unmetabolized folic acid present. Unlike natural folates (5-MTHF and 5-formyltetrahydrofolate), folic acid is not a normal metabolite and must be reduced in order to enter the folate cycle. It has been found that chronic liver exposure to folic acid in humans may actually induce saturation. This could very well be the reason why systemic circulation of unmetabolized folic acid has been reported. In addition, there is a growing body of evidence of folic acid supplementation playing a role in promoting the growth and development of certain cancers.
Source: Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr 2014 ajcn.080507; June 18, 2014.
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