Why CDG EstroDIM / Clear Estro DIM Pro?

Endocrine health is essential for metabolism support, allowing for the balance of estrogen, breast and prostate health. Hormones have important functions in every area of the body, being one of the most important, as they interact with every physiological system. Hormones are chemical messengers, networking with the cells all throughout the body, especially tissues more sensitive to them.

The primary message of hormones is to promote the growth of cells, creating cellular replication. For this reason, hormones are critical in the process of human development and tissue repair. Orthomolecular research states that, “supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance…by keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites (such as I3C and DIM) work together to reduce hormone overload and maintain cellular health.”

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The metabolism is supported primarily from eating cruciferous vegetables, becoming particularly beneficial for breast and prostate health. These cruciferous vegetables are thought to be derived from the group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed, or chewed, the enzyme myrosinase hydrolyses these glucosinolates into other compounds, including DIM. These compounds are often thought to be responsible for the many cellular activities that lead to general hormone health.

Orthomolecular states that, “CDG EstroDIM is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism.” CDG EstroDIM includes a variety of elements necessary for proper hormone activivty, allowing for a healthier estrogen level and benefits to other anatomical tissues. Studies have shown that I3C and DIM suggests that the phytonutrients found in cruciferous vegetables have strong potential for supporting breast, cervical, uterine and prostate health.

Orthomolecular private-labeled this product for us. Find Clear Estro DIM Pro HERE.

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I3C (indole-3-carbinol) is a naturally occurring compound found in many cruciferous vegetables. After the ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds have shown significant results in impacting metabolic shifts and cellular activities for overall improved health. I3C, in particular, has shown to support healthy cellular function within estrogen metabolism.


Diindolylmethane (DIM) is a phytonutrient and plant indole also found in cruciferous vegetables that has shown significant effects in enhancing proliferation of healthy cells and cellular activities. DIM has been shown to promote healthy estrogen metabolites and enhances the potential for greater antioxidant activity.

Calcium D-Glucarate

Calcium D-Glucarate is the supplemental calcium salt form of D-glucaric acid, a substance formulated within the body and obtained through consumption of certain fruits and vegetables. Calcium D-Glucarate has had a number of studies done to show its ability to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This, in turn, allows for the body to detoxify estrogens, foreign molecules and fat-soluble toxins.


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