What Does Mucosagen Support?

Mucosagen is a formula of compounds that work synergistically to help support barrier function of the gastrointestinal lining, as well as liver detoxification and maintaining proper inflammatory balance. The mucosal epithelium serves multiple purposes including the absorption of nutrients in the daily diet and digestion, while simultaneously serving as a barrier that protects against unwanted food particles, toxins and microorganisms from passing directly into the body.

Under healthy conditions, the GI tract contains a semi-permeable epithelial mucosal barrier which protects against the unwanted passage of food antigens, toxins, and microorganisms from crossing directly into the bloodstream. Several factors can affect the integrity of the epithelial barrier including medications (particularly NSAIDs), stress, alcohol intake, injury, trauma, microbial imbalance and poor nutrition. Reducing the impact of these factors and preserving a healthy GI tract is critical for maintaining long-term health.

In order to protect the mucosal barrier, a thick, complex layer of mucus is produced. Mucosagen includes L-glutamine, gamma oryzanol, N-acetyl glucosamine and lactoferrin to help support the health of the intestinal mucosal barrier and maintain healthy mucin production.

So, what ingredients are in Mucosagen? Read more about each ingredient below.


L-glutamine is an amino acid, serving as the primary source of fuel for the small intestines and is used to maintain mucosal growth, structure and function. Under stress, L-glutamine has been shown to become a conditionally essential amino acid, being the primary fuel source for the gut mucosal lining to maintain and the health of gut tissue, while also helping to regenerate a healthy mucosal barrier.

Gamma Oryzanol

Gamma oryzanol is a natural component of rice bran oil. Rice bran oil includes about 1-2% gamma oryzanol, which is a highly effective antioxidant in the GI tract. Gamma oryzanol has also been shown to protect gastric mucosa from free radical stress while maintaining normal inflammatory balance by inhibiting NFkB in macrophages.

N-Acetyl Glucosamine & N-Acetyl Cysteine

N-acetyl glucosamine is the acetylated form of glucosamine and has been shown to increase the production of mucus within the GI tract. Those experiencing GI challenges are often deficient in colonic mucus, so supplementing with N-acetyl glucosamine can help balance and protect mucosal production.

N-acetyl cysteine (NAC) is a sulfyhydryl containing amino acid that is commonly used to support liver and gut health.NAC is an effective precursor to the major antioxidant in the body, glutathione. NAC supplementation has been shown to effectively increase intracellular glutathione levels. NAC also stimulates a specific detoxification pathway in the liver called glutathione conjugation.

Lactoferrin & Silymarin

Lactoferrin is a glycoprotein that is naturally found in colostrum, the milky fluid produced by the mammary glands. Lactoferrin is key in supporting immune health and helps maintain normal microbial and inflammatory balance in the GI tract.

The extract of milk thistle has silymarin, the biologically active component found in the seeds and leaves. Milk thistle is an annual plant indigenous to Europe and the United States and has been used for centuries as an herbal medicine to boost liver function. Silymarin protects the liver through several mechanisms, including inhibiting lipid peroxidation, supporting liver detoxification through enhancement of the liver’s glucuronidation pathways, and protecting against glutathione depletion.

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Information provided by Orthomolecular Products.