Why Green Tea Extract?

I write about EGCg elsewhere because it simply does so many things. Green tea (Camelia sinensis) is an abundant source of antioxidants – notably, epigallocatechin gallate (EGCg), the most potent reducer of IL-6, a powerful pro-inflammatory cytokine. Previous studies have suggested that supplements of green tea extract may confer a variety of cardiovascular and cancer protective effects.

More recently, Nagi B. Kumar, from the H. Lee Moffitt Cancer Center & Research Institute (Florida, United States), and colleagues enrolled 97 men who had premalignant prostate lesions or high-grade intraepithelial neoplasia.  Tracking for changes in high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP), study participants were randomly assigned to receive either a supplement containing green tea extract (400 mg EGCg), or placebo, for one year.

Green Tea Leaves

The researchers observed that the men who received the green tea supplement experienced reduced combined rates of HGPIN/ASAP, as well as decreased levels of Prostate Specific Antigen (PSA). The study authors report that, “Daily intake of a standardized, decaffeinated catechin mixture containing 400 mg EGCg per day for 1 year accumulated in plasma and was well tolerated but did not reduce the likelihood of PCa in men with baseline [high-grade prostatic intraepithelial neoplasia] or [atypical small acinar proliferation].”

EGCg may cause apoptosis in oral cancer cells while leaving normal cells alone, according to researchers at Penn State. Previous studies had shown that EGCg destroyed oral cancer cells without harming healthy ones, but researchers did not understand the mechanism of action behind this. This study, published online in Molecular Nutrition and Food Research, demonstrates that EGCg may trigger apoptosis in the mitochondria, leading to cell death.

The researchers determined that the protein known as sirtuin 3 is critical to the process. Sirtuin 3 plays an essential role in antioxidant activity and in mitochondrial function in many tissues throughout the body. They conclude that EGCg’s potential ability to selectively regulate the activity of sirtuin 3 (to turn it off in cancer cells and to turn it on in normal cells) is a key factor, and may be relevant to many kinds of cancers.

EGCg is also a powerful assistant in the fight against bone loss. Both Primary Osteoporosis and bone loss due to pathological reasons (cancer), involves elevated IL-6 levels. Clear EGCg may be a beneficial nutrient to anyone’s protocol should bone loss exist.

IMPORTANT

Most Green Tea from China is heavily contaminated (this includes supplements!!!). We ONLY use very reputable companies (now using a de-caffeinated EGCg that is spot-checked for heavy metals and pesticides) that run labs on EVERY batch!

What we recommend for our patients: 

Teavigo 

 

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