Chronic Inflammation that KILLS
Genetic Defects / HISTADELIA
Another symptom of hidden autoimmune disorders and genetic variants:
Individuals with high-histamine levels and chronic inflammation must look at THREE sources:
- Histamine and other inflammatory chemicals produced in the GUT due to dysbiosis (imbalanced microbiota), food sensitivities, Leaky Gut syndrome, etc.
- Consumption of high amounts of histamine foods with a decreased ability to digest them due to genetic defects in ABP1 genes.
- Inability to rid excess histamine from tissues due to HNMT gene defects.
As a consequence, these individuals overproduce and retain excessive levels of histamine. Histamine is a substance in the body that has wide ranging effects. There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes, blood vessels, etc. For some individuals, high levels of blood histamine (called histadelia) have psychological, behavioral, and cognitive symptoms.
Many patients with obsessive-compulsive tendencies, “oppositional-defiant disorder,” or seasonal depression are under-methylated, which is associated with low serotonin levels. Often with inhalant allergies, frequent headaches, perfectionism, competitiveness and other distinctive symptoms and traits. Tend to be very low in calcium, magnesium, methionine, and vitamin B-6 with excessive levels of folic acid. People with histadelics have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters. Unfortunately, histadelics often have nasty side effects with these medications.
Histamine excess can be manifest as asthma, vasomotor rhinitis, allergic skin disorders with pruritis, excess stomach acid production (acts as a gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and bronchial secretions, and certain types of vascular headaches. This is the basis of anti-histamine medications. Excessive histamine results because of the inadequate methylation in liver detoxification. Histamine opposes adrenalin in its effects and as expected fatigue occurs just as it occurs in adrenal exhaustion.
Biochemical treatment revolves around antifolates, especially calcium and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.
Methylation is involved in DNA synthesis, masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve myelination, carnitine and coenzyme Q 10 synthesis. The relationship of mood and behavior to Histadelia is due to the fact that methylation is involved in neurotransmitter synthesis.
See HERE for more information to decrease histamine levels.