What is Ubiquinol?

Ubiquinol is the reduced, active antioxidant form of coenzyme Q10 (CoQ10). Produced naturally within the body, ubiquinol is CoQ10 that has been converted into a substance necessary for use in cellular energy production. In addition to its critical role in energy production, CoQ10 is one of the most powerful known lipid-soluble antioxidants, protecting cells, organs and tissues from damage caused by oxidative stress and free radicals. For those who cannot efficiently convert ubiquinone to ubiquinol on their own, this patented, lipid- stabilized Ubiquinol formula ensures maximum bioavailability and cell protection.

Kaneka Ubiquinol^™ is derived from the world’s most recognized and researched CoQ10 ingredient for 30 years. Kaneka Ubiquinol^™ is a remarkably different product made by one of the most trusted companies in the nutritional ingredient industry. It is one of the strongest lipid-soluble antioxidant available providing defense against oxidative damage to the body’s cells, including lipids, proteins and DNA. It also plays an essential role in cellular ATP (energy) production.

Overview

CoQ10, or ubiquinone, is a lipid-soluble antioxidant which is found in every cell in the body. CoQ10 is abundant in the mitochondrial membrane and plays an important role in the synthesis of adenosine triphosphate (ATP), a molecule of chemical energy upon which all cellular functions depend. The synthesis of ATP within the mitochondria is a multi-step series of biochemical reactions called the electron transport chain. As a coenzyme, CoQ10 is required for several enzymatic reactions required to produce cellular energy and to protect the body against free radicals produced during this process. To maintain energy production, mitochondrial CoQ10 is continuously recycled from ubiquinone, its ATP production state, to ubiquinol, its antioxidant, free radical scavenging state. CoQ10, has been shown to extend cell life and benefit high-energy systems like the cardiovascular, neurological, and immune systems.

CoQ10 Depletion†

The body’s ability to produce and metabolize CoQ10 has been reported to decrease with age. CoQ10 deficiency may be caused by insufficient dietary intake of CoQ10, impairment in CoQ10 production, drug-induced CoQ10 depletion, gene mutations, and oxidative stress. HMG-CoA reductase is an enzyme required for the synthesis of cholesterol and CoQ10. Cholesterol lowering medications inhibit this enzyme in order to reduce cholesterol synthesis but may also deplete CoQ10 status simultaneously. In the event of CoQ10 depletion, supplementation can improve CoQ10 status and help maintain optimal levels in the body.

Antioxidant Protection†

Oxidative stress is a condition that occurs when there is an imbalance of free radicals and antioxidants required to neutralize them, leading to oxidative damage. The extent of oxidative stress depends on the rate at which free radicals are generated, the level of antioxidant reserves, and the rate of repair of cellular and tissue damage that has occurred. This process has a significant impact on the body’s aging process. Ubiquinol is an electron donor because it has two hydroxyl groups. The electrons that ubiquinol donates help to neutralize free radicals thereby providing significant protection against toxic oxidative reactions in the body.

Cholesterol†

CoQ10 appears to be a preventive factor for reducing low- density lipoprotein (LDL) oxidation- a major factor for supporting healthy cholesterol levels.1 In a study examining the antioxidant effects of ubiquinol versus vitamin E, ubiquinol significantly reduced LDL lipid peroxidation more efficiently than vitamin E.1