Blocking Testosterone and IL-6
Many oncologists that treat prostate cancer patients insist on using androgen-deprivation therapy (ADT) that blocks male hormone production and release. The theory is that testosterone increases the growth of prostate cancer is based on the androgen receptor on cancer cells and its high-affinity binding of dihydrotestosterone (derived from testosterone) which can block this receptor.
The general positive response many prostate cancer patients have after beginning ADT reflects a dependence on androgen in tumor cell proliferation, at least in early stage disease. However, studies have shown that subsequent to androgen deprivation therapy, prostate cancers can recur and progress to a terminal stage despite reduced circulating testosterone.
There is research that shows that a specific androgen receptor, AR 3, is activated by testosterone stimulating normal prostate growth. In prostate cancer, it is thought that testosterone over-effects these receptors in a sense. Somehow the receptors become hyper-reactant to testosterone causing excess growth. This is called AR 3 overexpression. It is thought that certain genes (TIF2 and SRC1) can become expressed which then contribute the AR 3 overexpression.
Reducing testosterone with castration or ADT has proven to help early stage prostate cancer but researchers are still puzzled as to the mechanism of cancer return and re-growth in many patients. Using Lupron or another brand of ADT can dramatically reduce PSA levels and even greatly slow growth for a period of time. Then the cancer tends to reappear, “with a vengeance”. How can we address this?
It has been known that elevated interleukin-6 (IL-6), a major mediator of the inflammatory response, has been implicated in androgen receptor (AR 3) activation, cellular growth and differentiation. Since IL-6 plays an important role in the development and progression of prostate cancer, is there a natural way to reduce these levels and slow the expression of the TIF2 and SRC1 genes?
Andrographis & EGCg
Enter two natural product – Andrographis and EGCg. The traditional Chinese and Indian medicinal plant Andrographis paniculata, as well as EGCg, an active catechin from Green Tea have been shown to inhibit IL-6 expression and suppress IL-6–mediated signals.
Furthermore, andrographis inhibits cell viability and induces apoptotic cell death in both androgen-stimulated and castration-resistant human prostate cancer cells without causing significant toxicity to normal immortalized prostate epithelial cells.
What we use:
ViraClear – for Andrographis
Teavigo – for EGCg
Saw palmetto is an herb used to treat the symptoms of benign prostatic hyperplasia (BPH). In vitro studies have found that saw palmetto inhibits growth of prostatic cancer cells and may induce apoptosis. Other studies revealed that Saw Palmetto down-regulated IL-6 as well as androgen receptor (AR 3).
It has also been shown to reduce Cox-2 expression, an inflammatory marker associated with an increased incidence of prostate cancer so use can also be preventative.
What we use with Saw Palmetto:
Chrysin is a natural flavone commonly found in honey that has been shown to be an antioxidant agent. Studies have shown it to have an antiproliferative effect on prostate cancer cells inducing apoptosis is several cell lines.
Another study revealed that Chrysin inhibited insulin-induced expression of HIF-1α by reducing its stability. I talk about HIF-1α in my Cancer Genes book because it closely relates to many cancer’s ability to utilize lactic acid from glucose as a fuel source. Inhibition of HIF-1α by chrysin also may inhibit vascular endothelial growth factor (VEGF) expression thereby reducing the vasculization of tumors.
What we use with Chrysin:
Haelan 951 –
Buy Stop Treating Cancer & Start Treating the Cause to learn more about hormone health & regulation.
Check out my blog on woman’s hormone health to learn more about specific nutrients that help with hormone regulation.
Dr. Conners graduated with his doctorate from Northwestern Health Sciences University in 1986 and has been studying alternative cancer care for over 20 years. He holds AMA Fellowships in Regenerative & Functional Medicine and Integrative Cancer Therapy.
He is the author of numerous books including, Stop Fighting Cancer and Start Treating the Cause, Cancer Can’t Kill You if You’re Already Dead, Help, My Body is Killing Me, Chronic Lyme, 3 Phases of Lyme, 23 Steps to Freedom, and many more you can download for FREE on our books page.