An Introduction to Oxaloacetate

Oxaloacetate, a compound renowned for its resemblance to calorie restriction, has garnered significant attention for its potential health benefits. Collaborative research efforts between Terra Biological, UCSD, and UCLA have revealed promising results in terms of longevity, emotional well-being, and fatigue management. In this blog post, we will delve into the scientific foundations of oxaloacetate, its profound effects on the body, and its potential applications in promoting overall health and well-being.

Clinical Trials and Studies on Oxaloacetate with Terra Biological

Extensive studies conducted by Terra Biological since its inception in 2006 have demonstrated the remarkable potential of oxaloacetate in extending the lifespan of small, short-lived animals by up to 50%. By activating specific molecular pathways associated with calorie restriction, oxaloacetate exhibits the ability to stimulate beneficial proteins within the body. Caloric restriction has long been acknowledged as a means to promote longevity, reduce inflammation, and combat chronic diseases across various species, making oxaloacetate a captivating area of study.

Oxaloacetate and PMS, Emotional Support

One notable application of oxaloacetate lies in its impact on emotional symptoms associated with premenstrual syndrome (PMS) in women. Clinical trials have revealed that oxaloacetate supplementation helps balance blood sugar levels, preventing glucose shortage in the brain during PMS. This balance leads to a significant reduction in emotional symptoms such as sadness, irritability, and anger. The positive feedback received from women who experienced relief from PMS symptoms underscores the potential of oxaloacetate as a natural approach to addressing emotional challenges.

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Combating Chronic Fatigue Syndrome with Oxaloacetate

The benefits of oxaloacetate extend beyond PMS management. Recent clinical trials conducted by Terra Biological have explored its efficacy in combating fatigue. Debilitating conditions like chronic fatigue syndrome (CFS) and long COVID fatigue affect millions of individuals worldwide. Oxaloacetate has shown promise in normalizing energy production at the cellular level, particularly by counteracting the Warburg effect observed in CFS and cancer cells. By reducing reliance on inefficient fermentation processes, oxaloacetate helps restore energy production to a more optimal state, leading to a reduction in fatigue levels.

A double-blind, placebo-controlled crossover trial conducted by Terra Biological exhibited impressive results in combating fatigue. Participants with chronic fatigue syndrome experienced a 25% reduction in fatigue after six weeks of high-dose oxaloacetate supplementation. Similarly, individuals suffering from long COVID fatigue witnessed a significant 48% reduction in fatigue levels within the same timeframe. These findings offer hope for those grappling with persistent fatigue, particularly in the aftermath of COVID-19.

The mechanism of action behind oxaloacetate’s impact on fatigue management involves its influence on cellular energy production. By promoting the use of glucose in mitochondria instead of relying on fermentation, oxaloacetate helps restore normal energy metabolism. This normalization aids in reducing fatigue and improving overall energy levels. Additionally, oxaloacetate has been shown to inhibit hypoxia-inducible factor 1 (HIF1), a key regulator of the Warburg effect. This inhibition further contributes to the restoration of optimal energy production.

Considering the significant number of individuals worldwide affected by chronic fatigue syndrome and long COVID fatigue, oxaloacetate represents a potential game-changer in their management. The ability to address the core energy production issues associated with these conditions offers hope for improved quality of life for millions. By providing a natural and safe alternative, oxaloacetate holds promise as a therapeutic option, particularly when combined with other supportive treatments.

Other Oxaloacetate Therapeutic Applications

Oxaloacetate, a compound that mimics the effects of calorie restriction, has shown immense potential in promoting longevity, managing emotional symptoms of PMS, and combating fatigue associated with chronic fatigue syndrome and long COVID. Through its influence on cellular energy metabolism and the inhibition of the Warburg effect, oxaloacetate offers an exciting avenue for further research and therapeutic applications. As experts continue to explore the multifaceted benefits of oxaloacetate, its potential to revolutionize the fields of longevity, mental well-being, and fatigue management becomes increasingly evident.