While Resveratrol is perhaps, as my title states, the most researched anti-aging product on the market, it is NOT just an anti-aging product. Numerous articles show its benefit for cancer to hormonal issues, and cardiovascular support to brain health. Resveratrol is indeed a must-purpose nutrient.

Clear Resveratrol Plus is an exciting combination of two powerful antioxidants, resveratrol and quercetin. Damage from free radicals is a primary driver of compromised health, and this may particularly affect the cardiovascular system (blood vessels) and neurons—especially the neurons’ mitochondria, which are the parts of the cell that generate energy.

Proper functioning of the mitochondria is crucial for overall health. Excessive oxidative damage (damage from free radicals) is also implicated in the aging process. Antioxidants combat free radicals and help reduce the impact of their damage. Through decreasing free radical damage, antioxidants may also mimic the beneficial effects of a reduced calorie diet.

This product is great to help overcome inflammation – especially brain inflammation. Dr. Conners references it in his talks on microglial priming (damaged immune cells in the brain) that is common post-concussion, post-chemo, and in chronic Lyme.

Overview

Nrf2 is a transcription factor that regulates the antioxidant response of the body.1 It is the primary cellular defense against the cytotoxic effects of oxidative stress.2 This key protein is found inside a cell and is inactive until it is released by an Nrf2 activator. Once activated, Nrf2 migrates into the nucleus and binds to DNA at the location of the master antioxidant regulator, the antioxidant response element (ARE).3 Studies suggest Nrf2 plays an important role in supporting the activation of cellular antioxidant systems, as well as maintaining normal inflammatory balance.4,5 A number of fruit and vegetable compounds have been shown to activate Nrf2 and ARE, and increase antioxidant potential.6-9 It is believed that these compounds have a protective effect on the body, help maintain normal inflammatory balance, and induce cellular longevity.10

Resveratrol

Resveratrol is found in peanuts, berries, red wine (from the skin of red grapes), and in the Japanese knotweed plant, also known as Polygonum. Resveratrol is produced by certain plants to act as a natural pesticide, protecting the plant from environmental insults. In the case of grapes, it concentrates in the skin and protects the plant from mold and bacterial infection. The harsher the climate in which grapes grow, the more protection the grapes need, and therefore, wine produced from those grapes has a higher amount of resveratrol.

Resveratrol may have a similar protective effect against natural physiological damage when consumed in the diet. The resveratrol in Clear Resveratrol Plus has been standardized to all trans resveratrol, as the opposite or “cis” form may not have the same beneficial biological activity. It is also more highly concentrated, to provide a greater amount of resveratrol than an individual would be likely to obtain through a reasonable diet.

Quercetin

Quercetin has been called “king of the flavonoids” because of its powerful antioxidant properties and its ability to support a healthy inflammatory response in the body. It is found in many foods that are recognized for their health benefits, such as red onions, apples, olive oil, dark berries and grapes, capers, salad greens, and culinary herbs such as dill, cilantro, watercress, and radicchio. (Quercetin contributes to the bold colors of these foods.)

Synergy between resveratrol and quercetin indicates that the two compounds together may be more beneficial than either one taken alone. Clear Resveratrol Plus also includes lecithin for more effective nutrient absorption

Made with non-GMO ingredients.

Cautions

Do not consume this product if you are pregnant or nursing. Consult your physician for further information.

References

  1. Wong SY, Tan MG, Wong PT, et al. Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK. Journal of neuroinflammation 2016;13(1):251.
  2. Wu KC, McDonald PR, Liu J, et al. Screening of natural compounds as activators of the keap1-nrf2 pathway. Planta medica 2014;80(1):97.
  3. Rajagopal S, Kumar RA, Deevi DS, et al. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. Journal of Experimental therapeutics and Oncology 2003;3(3):147-58.
  4. Mishra SK, Sangwan NS, Sangwan RS. Phcog Rev.: Plant Review Andrographis paniculata (Kalmegh): A Review. Pharmacognosy Reviews 2007;1(2):283-98.
  5. Li W, Khor TO, Xu C, Shen G, Jeong W-S, Yu S and Kong A-N. Activation of Nrf2-antioxidant signaling attenuates NFκB- inflammatory response and elicits apoptosis. Biochemical pharmacology. 2008;76:1485-1489.
  6. Surh Y-J, Kundu JK and Na H-K. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta medica. 2008;74:1526-1539.
  7. Surh Y-J and Na H-K. NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals. Genes & nutrition. 2008;2:313-317.
  8. Lee JH, Khor TO, Shu L, Su Z-Y, Fuentes F and Kong A-NT. Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacology & therapeutics. 2013;137:153-171.
  9. Gopalakrishnan A and Kong A-NT. Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells. Food and Chemical Toxicology. 2008;46:1257-1270.