What Is Japanese Knotweed Used For?
Japanese Knotweed (Polygonum cuspidatum, Chinese knotweed, Hu Zhang, Kojo, Itadori, Hojang) – Though this can act as a great Th1 stimulator and must be tested in individual patients, Japanese knotweed can work well to modulate the immune response. Studies have revealed anti-parasitic, antibacterial, antifungal, anticancer properties as well as central nervous system calming properties. It also protects the body against endotoxin damage from ‘die-off’ of bio-toxins killed through other sources. Other studies have shown it to be anti-inflammatory and may be extremely useful in calming Th17 inflammation in the brain as it crosses the blood-brain barrier readily.
Some bio-toxins (living organisms invading the body) can release compounds called matrix metalloproteinases (MMPs, of which there are several different types) that destroy our body’s tissue. Many anti-inflammatories that I highly recommend in this group have shown to help clear the body of these MMPs, but only one, Japanese knotweed, has proven to block several types of MMP production. It also contains Resveratrol, by itself a Th2 stimulant, but in combination with the whole herb, it acts to inhibit MMP levels as well. Other research has shown that it inhibits arachidonic acid metabolites that force the COX inflammatory pathways as well as iNOS (the ‘bad’ nitric oxide that causes inflammation in the brain). It has also been proven to interfere with nuclear factor-kappaB, a chemical linked to inflammation, autoimmune disorders and cancer. It helps regulate normal cell death (apoptosis) where that has been altered (in cancer), and just modulates the immune response, especially in the brain and spinal cord.
Knotweed has also show to increase circulation to the small vessels of the eye, ear, joints, heart and skin. I test all Cancer, Lyme, Hepatitis C, and other bio-toxic members on knotweed. It can also work well for acute infections.
What we use to regulate normal cell death & promote immune response:
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Dr. Conners graduated with his doctorate from Northwestern Health Sciences University in 1986. He holds AMA Fellowships in Regenerative & Functional Medicine and Integrative Cancer Therapy.
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