Vitamin D does a body GOOD

With ever-increasing evidence of the role of vitamin D in mental health issues, a new study shows that low vitamin D levels in first-onset psychosis correlate with function and mood 12 months later.

“Low vitamin D is commonly found in people with psychosis, but it is unclear whether this is a result of psychosis, a predisposing factor, or relating to common risk factors,” says Fiona Gaughran, MD, of the National Psychosis Service, South London and Maudsley NHS Foundation Trust, United Kingdom.

“Clinical trials are needed to determine whether screening and prescribing supplemental vitamin D is indicated in psychosis,” she added.

The findings were presented here at the 15th International Congress on Schizophrenia Research (ICOSR).

High Rate of Deficiency

Vitamin D deficiency occurring at various stages of development, including in utero, is linked to psychosis, a fact that prompted the investigators to examine the role of vitamin D in the early stages of the psychosis.

For the study, the researchers evaluated vitamin D levels in 166 patients (64% male) at first onset of psychosis and again 12 months later. Measurements were also collected from a separate group of 324 community patients who were known to have had psychosis for a period of approximately 15 years.

After adjusting for age, sex, ethnicity, and the season of sampling, patients with a first onset of psychosis were found to have a mean vitamin D level of just 13.64 ng/ml, significantly lower than the level of 20 ng/ml that is considered to be sufficient.

DO YOU BELIEVE IT? Vitamin D levels of 13???!!! That is HORRIBLE and what we often find in autoimmune patients!

Low levels of vitamin D at presentation correlated significantly with disease signs and symptoms 12 months after presentation, including lower overall Global Assessment of Function scores (P = .02), poorer function (P = .05), and higher scores on the Calgary Depression Scale for Schizophrenia (P = .01).

Correlations were also seen between lower vitamin D levels at 12 months and Positive and Negative Syndrome Scale (PANSS) scores (P = .03) and quality-of-life scores (P = .02).