The endocannabinoid system (ECS) is comprised of cannabinoid receptors, endocannabinoid molecules, and their metabolic enzymes. It is a crucial molecular system that the body uses to help maintain homeostasis.1

Discovered in the the 1990’s, the endocannabinoid system (ECS) is called the Master Regulator of Health. Perhaps the most important physiologic system involved in establishing and maintaining human health, the ECS is comprised of cell surface receptors sites, messenger molecules called endocannabinoids, and enzymes.

What is the Difference Between Phytocannabinoids and Endocannabinoids?

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The hemp plant makes phytocannabinoids that can help restore balance and homeostasis to the body. The primary phytocannabinoid in hemp is called cannabidiol (CBD). Endocannibinoids are made by the body and bind to ECS receptors and signal the up or down regulation of these specific functions, in order to maintain balance or homeostasis. A deficiency in endocannabinoids is believed to contribute to a wide variety of health challenges.

How to Choose a CBD Hemp Oil

For the best results, look for:

  • Organically grown
  • How is it extracted
  • What delivery system is utilized
  • Ensure there is 0.0% THC
  • Enhanced absorption (bioavailability)
  • Enhanced Entourage effect
  • Symbiotic immune support

What are the Key Extraction Processes?

When extracting Hemp Oil from the Hemp Plant, there are 2 processes that are commonly used:

  1. Solvent – Most economical but can damage beneficial terpenes and can leave a chemical residue. Used primarily to extract CBD isolates
  2. Supercritical CO2 – A clean extraction process that protects the heat sensitive terpenes and flavonoids.

What are the Different Types of Hemp-Derived CBD Oils?

  1. CBD Isolates: 99.9% pure crystallized cannabinoids with no terpenes or flavonoids.
  2. Full Spectrum Hemp: Contains over 100 naturally occurring compounds including cannabinoids (THC at 0.3%), terpenes and other nutrients.
  3. Broad Spectrum Hemp: Same as full spectrum with 0.0% THC.

What are Receptor Sites, What do They Regulate?

Receptor sites (predominantly CB1’s and CB2’s) are located in the brain, throughout the central and peripheral nervous systems and in other strategic locations throughout the body.

The receptors regulate a variety of actions in the body2:

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What is the Endocannabinoid System (ECS)? | Dr Kevin Conners, Conners Clinic


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  1. Leafly.com
  2. Mechanisms of CB1 receptor signaling