Research studies are showing that incorporating whole plant (full-spectrum) cannabinoids into a natural treatment regimen may improve anti-tumor effects in both hormone-sensitive and triple-negative breast cancers.

Hormone-sensitive breast cancers are classified using two biomarkers: hormonal receptors (estrogen receptor and progesterone receptor) and the HER2 oncogene. In a patient’s diagnosis this is denoted as ER+, PR+ and HER2+, with any combination of biomarkers possible.

In triple-negative breast cancer, which is a more aggressive malignancy, neither hormonal receptors nor the HER2 oncogene are expressed. This means that the cancer has no specific ties or drivers, so the patient is not a candidate for hormone or gene-specific treatments.

A study conducted on each of these cancer types found that THC-rich oil (whole plant cannabinoids) had more pronounced anti-tumor effects than single-molecule THC. The anti-tumor effect or “Entourage Effect” refers to the natural synergy between multiple cannabis compounds which, when combined, have a therapeutic impact much more powerful than the sum of cannabis’ individual components.

Specifically in hormone-sensitive breast cancers, whole plant cannabinoid oils have an average 15-25% greater anti-proliferative effect than single THC extracts.

The research study focused on 1:1 THC:CBD ratios, along with measurable amounts of CBG, THCa, caryophyllene, humulene, nerolidol, linalool and pinene.

Although I prefer patients seek individualized testing to determine which forms, brands, and dosages of cannabis are the best for them, I am comfortable recommending that any breast cancer patient consider incorporating some form of full-spectrum cannabinoid into daily supplement regimens. As always, strive to find organic sources.

Note: At this time, recreational cannabis is not legalized in Minnesota, so all THC-dominant cannabinoids must be purchased through a licensed medical professional.

For more information on Conners Clinic or to contact use, please visit or call our office at 651.739.1248.


  1. Andia, Alex. THC Versus Breast Cancer. Project CBD. [Online] March 18, 2019. [Cited: July 30, 2019.]
  2. Blasco-Benito, S, et al. Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. NCBI. [Online] June 27, 2018. [Cited: July 30, 2019.]